Electronic cigarettes (e-cigarettes) is a growing trend characterized by heating a chemical liquid to produce an aerosol containing nicotine and various toxic substances. Inhalation of these aerosols triggers physiological changes, including increased oxidative stress and cardiovascular strain . The present study investigated the association between vaping and cardiovascular, renal, and hematological parameters in 42 male participants (aged 18–50 years) in Soran City. Participants were stratified into two groups: a vaping group (22 regular e-cigarette users) and a control group (20 non-users). Blood pressure metrics (systolic blood pressure (SBP), diastolic blood pressure (DBP)), heart rate (HR), random blood sugar (RBS), and total cholesterol were measured. Serum creatinine and aspartate aminotransferase (AST) levels were quantified via an automated chemical analyzer, and malondialdehyde (MDA) was measured to assess oxidative stress . Complete blood counts (CBC) were also performed to determine hematological changes . Results demonstrated that SBP and HR were significantly elevated in the vaping group compared to the control group . Additionally, the vaping group exhibited a significant elevation in serum MDA levels, indicating high oxidative stress . Significant increases were also observed in hematological parameters, including red blood cell (RBC) count, white blood cell (WBC) count, hemoglobin (HGB), and platelet count (PLT). While SBP and HR rose, DBP, serum creatinine, AST, RBS, and cholesterol levels showed no statistically significant differences, although slight upward trends were noted in some markers . In conclusion, the study reveals that vaping is associated with significant increases in systolic blood pressure, heart rate, and markers of oxidative stress (MDA). Furthermore, vaping leads to a significant rise in various blood cell parameters, likely due to chronic tissue hypoxia and systemic inflammation. These findings suggest that vaping may have detrimental effects on cardiovascular health and overall physiological balance, highlighting the importance of understanding its health risks to protect public well-being in the region.
